U-shaped curve revealed for association between fish consumption and atrial fibrillation

Public release date: 24-Jun-2013
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Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology

Moderation seems to be key when it comes to eating fish to prevent atrial fibrillation

Athens, Greece, 24 June 2013. Moderation seems to be key when it comes to eating fish to prevent atrial fibrillation (AF) according to an observational study presented at the EHRA EUROPACE congress held 23 to 26 June in Athens, Greece.

The study found a U-shaped association between consumption of marine n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of developing AF, with people who have both low and high intakes found to suffer more from AF than those with median intakes. The lowest risk of AF was found in those who consumed around 0.63 g marine n-3 PUFA per day, which corresponds to around two servings of fatty (oily) fish per week.

Earlier studies have reported that regular consumption of fish can exert beneficial effects in preventing the development of AF. Notably, in the Cardiovascular Health study, which included 4,815 participants, a 28% lower risk of AF was observed among people who consumed fish one to four times per week compared with those who ate fish less than once per month. However, such observed associations have not been confirmed in all cohort studies?8.

In the current study, Doctor Thomas Rix and colleagues from Aalborg University Hospital in Denmark, set out to examine the hypothesis that a negative association exists between the development of AF and consumption of n-3 PUFA. "Since AF is present in over six million people in Europe and associated with considerable morbidity, mortality and economic costs, preventing AF by achievable dietary changes would be of major public interest," said Dr. Rix.

The investigators made use of the Danish Diet, Cancer and Health cohort 9, which between 1993 and 1997 enrolled a total of 57,053 Danish participants aged 50 to 64 years. The study, funded by the Danish Cancer society, had been initiated with the primary objective of exploring the role of diet in the development of cancer. Baseline data recorded for the study included a semi quantitative food frequency questionnaire with detailed questions about the consumption of fish and food products containing fish that enabled the calculation of average n-3 PUFA intakes. Levels of N-3 PUFA/day were divided into quintiles: with quintile 1 representing 0.00-0.38g marine n-3 PUFA/ day; quintile 2 representing 0.39-0.53g marine n-3 PUFA/day; quintile 3 representing 0.54 to 0.73 g marine n-3 PUFA/day; quintile 4 0.74 to 0.99 g marine n-3 PUFA/day; and quintile 5 1.00-7.22 g marine n-3 PUFA/day.

Follow-up of AF events in the population was undertaken using the Danish National Patient Registry, which recorded discharge diagnoses from hospital admissions, emergency rooms and outpatient clinics. The registry was facilitated by the Danish practice of identifying every citizen with a unique personal identification number that enables cross links to be made between different national registries.

Altogether a total of 3,425 incident cases of AF were registered during 13.6 years of follow-up. When data was analysed in a multivariate Cox regression model, in comparison to the lowest quintile a 9% lower risk of AF was seen for the second quintile (HR 0.91 95% CI 0.81-1.02); a 13 % lower risk of AF was seen for the third quintile (HR 0.87, 95% CI 0.78-0.98, p=0.02); a 4% lower rate was seen for the fourth quintile (HR 0.96, 95% CI 0.86-1.07) and a 3% increased rate was seen for the 5th quintile (HR 1.03, 95% CI 0.92-1.15).

"The 13% observed lower risk of AF seen at moderate intakes of marine n-3 PUFA compared with low intakes may be related to a reduction in ischemic heart disease and anti-inflammatory effects in addition to direct anti arrhythmic effects," said Dr. Rix. He noted that in one study, treatment with 1.8g n-3PUFA/day in patients with low intakes of fish resulted in prolongation of the atrial effective refractory period and less inducible AF, both in subjects with AF8 and subjects without AF10.

The biological mechanisms behind the higher risk of AF observed for high intakes of n-3 PUFA compared to moderate intakes were more difficult to explain," said Dr. Rix. "We can only speculate that the balance between AF inhibiting and AF promoting effects can change according to co morbidities and intakes of marine n-3PUFA. This is the first time that such an association has been shown and it needs to be explored in further studies. However, it may help explain some of the contradictory results obtained in earlier studies."

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 24-Jun-2013
[ | E-mail | Share ]

Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology

Moderation seems to be key when it comes to eating fish to prevent atrial fibrillation

Athens, Greece, 24 June 2013. Moderation seems to be key when it comes to eating fish to prevent atrial fibrillation (AF) according to an observational study presented at the EHRA EUROPACE congress held 23 to 26 June in Athens, Greece.

The study found a U-shaped association between consumption of marine n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of developing AF, with people who have both low and high intakes found to suffer more from AF than those with median intakes. The lowest risk of AF was found in those who consumed around 0.63 g marine n-3 PUFA per day, which corresponds to around two servings of fatty (oily) fish per week.

Earlier studies have reported that regular consumption of fish can exert beneficial effects in preventing the development of AF. Notably, in the Cardiovascular Health study, which included 4,815 participants, a 28% lower risk of AF was observed among people who consumed fish one to four times per week compared with those who ate fish less than once per month. However, such observed associations have not been confirmed in all cohort studies?8.

In the current study, Doctor Thomas Rix and colleagues from Aalborg University Hospital in Denmark, set out to examine the hypothesis that a negative association exists between the development of AF and consumption of n-3 PUFA. "Since AF is present in over six million people in Europe and associated with considerable morbidity, mortality and economic costs, preventing AF by achievable dietary changes would be of major public interest," said Dr. Rix.

The investigators made use of the Danish Diet, Cancer and Health cohort 9, which between 1993 and 1997 enrolled a total of 57,053 Danish participants aged 50 to 64 years. The study, funded by the Danish Cancer society, had been initiated with the primary objective of exploring the role of diet in the development of cancer. Baseline data recorded for the study included a semi quantitative food frequency questionnaire with detailed questions about the consumption of fish and food products containing fish that enabled the calculation of average n-3 PUFA intakes. Levels of N-3 PUFA/day were divided into quintiles: with quintile 1 representing 0.00-0.38g marine n-3 PUFA/ day; quintile 2 representing 0.39-0.53g marine n-3 PUFA/day; quintile 3 representing 0.54 to 0.73 g marine n-3 PUFA/day; quintile 4 0.74 to 0.99 g marine n-3 PUFA/day; and quintile 5 1.00-7.22 g marine n-3 PUFA/day.

Follow-up of AF events in the population was undertaken using the Danish National Patient Registry, which recorded discharge diagnoses from hospital admissions, emergency rooms and outpatient clinics. The registry was facilitated by the Danish practice of identifying every citizen with a unique personal identification number that enables cross links to be made between different national registries.

Altogether a total of 3,425 incident cases of AF were registered during 13.6 years of follow-up. When data was analysed in a multivariate Cox regression model, in comparison to the lowest quintile a 9% lower risk of AF was seen for the second quintile (HR 0.91 95% CI 0.81-1.02); a 13 % lower risk of AF was seen for the third quintile (HR 0.87, 95% CI 0.78-0.98, p=0.02); a 4% lower rate was seen for the fourth quintile (HR 0.96, 95% CI 0.86-1.07) and a 3% increased rate was seen for the 5th quintile (HR 1.03, 95% CI 0.92-1.15).

"The 13% observed lower risk of AF seen at moderate intakes of marine n-3 PUFA compared with low intakes may be related to a reduction in ischemic heart disease and anti-inflammatory effects in addition to direct anti arrhythmic effects," said Dr. Rix. He noted that in one study, treatment with 1.8g n-3PUFA/day in patients with low intakes of fish resulted in prolongation of the atrial effective refractory period and less inducible AF, both in subjects with AF8 and subjects without AF10.

The biological mechanisms behind the higher risk of AF observed for high intakes of n-3 PUFA compared to moderate intakes were more difficult to explain," said Dr. Rix. "We can only speculate that the balance between AF inhibiting and AF promoting effects can change according to co morbidities and intakes of marine n-3PUFA. This is the first time that such an association has been shown and it needs to be explored in further studies. However, it may help explain some of the contradictory results obtained in earlier studies."

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/esoc-ucr062013.php

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Stuntwoman, pilot killed in Ohio air show crash

CINCINNATI (AP) ? A budget analyst with a daredevil streak, Jane Wicker knew she was taking a risk when she signed up to entertain thousands of spectators at the Vectren Air Show near Dayton.

She said in a TV interview she felt confident of her ability and said on her website that lots of practice makes her signature stunt a "managed risk." She planned to hang underneath the plane's wing by her feet and sit on the bottom of the airplane while it was upside-down.

It wasn't clear Saturday what went so wrong. The biplane glided through the sky, rolled over, then crashed and exploded into flames, killing the wing walker and the pilot, authorities said. No one else was hurt.

A video posted on WHIO-TV shows the small plane turn upside-down as the performer sits on top of the wing. The plane then tilts and crashes to the ground, erupting into flames as spectators screamed.

Ian Hoyt, an aviation photographer and licensed pilot from Findlay, was at the show with his girlfriend. He told The Associated Press he was taking photos as the plane passed by and had just raised his camera to take another shot.

"Then I realized they were too low and too slow. And before I knew it, they hit the ground," he said.

He couldn't tell exactly what happened, but it appeared that the plane stalled and didn't have enough air speed, he said. He credited the pilot for steering clear of spectators and potentially saving lives.

"Had he drifted more, I don't know what would have happened," Hoyt said. He said he had been excited to see the show because he'd never seen the scheduled performer ? wing walker Jane Wicker ? in action.

The show was canceled for the rest of the day, but organizers said events would resume Sunday and follow the previous schedule and normal operations. The National Transportation Safety Board said it is investigating the crash.

On the video, the announcer narrates as the plane glides through the sky and rolls over while the stuntwoman perches on a wing.

"Now she's still on that far side. Keep an eye on Jane. Keep an eye on Charlie. Watch this! Jane Wicker, sitting on top of the world," the announcer said, right before the plane makes a quick turn and nosedive.

Federal records show the 450 HP Stearmans was registered to Wicker, who lived in Loudon, Va. A man who answered the phone at a number listed for Wicker on her website said he had no comment and hung up.

One of the pilots listed on Wicker's website was named Charlie Schwenker. A post on Jane Wicker Airshows' Facebook page announced the deaths of Wicker and Schwenker, and asked for prayers for their families.

A message left at a phone listing for Charles Schwenker in Oakton, Va., wasn't immediately returned.

Dayton International Airport spokeswoman Linda Hughes and Ohio State Highway Patrol Lt. Anne Ralston confirmed that a pilot and stunt walker had died but declined to give their names. The air show also declined to release their identities.

Another spectator, Shawn Warwick of New Knoxville, told the Dayton Daily News that he was watching the flight through binoculars.

"I noticed it was upside-down really close to the ground. She was sitting on the bottom of the plane," he said. "I saw it just go right into the ground and explode."

Thanh Tran of Fairfield said he could see a look of concern on the wing walker's face just before the plane went down.

"She looked very scared," he said. "Then the airplane crashed on the ground. After that, it was terrible, man ... very terrible."

Wicker's website says she responded to a classified ad from the Flying Circus Airshow in Bealeton, Va., in 1990, for a wing-walking position, thinking it would be fun. She was a contract employee who worked as a Federal Aviation Administration budget analyst, the FAA said.

She talked to WDTN-TV in an interview this week about her signature stunt.

"I'm never nervous or scared because I know if I do everything as I usually do, everything's going to be just fine," she told the station.

Wicker wrote on her website that she had never had any close calls.

"What you see us do out there is after an enormous amount of practice and fine tuning, not to mention the airplane goes through microscopic care. It is a managed risk and that is what keeps us alive," she wrote.

In 2011, wing walker Todd Green fell 200 feet to his death at an air show in Michigan while performing a stunt in which he grabbed the skid of a helicopter.

In 2007, veteran stunt pilot Jim LeRoy was killed at the Dayton show when his biplane slammed into the runway while performing loop-to-loops and caught fire.

Organizers were presenting a trimmed-down show and expected smaller crowds at Dayton after the Air Force Thunderbirds and other military participants pulled out this year because of federal budget cuts.

The air show, one of the country's oldest, usually draws around 70,000 people and has a $3.2 million impact on the local economy. Without military aircraft and support, the show expected attendance to be off 30 percent or more.

___

Thomas reported from Philadelphia. Associated Press writers Kerry Lester in Chicago and Randy Pennell in Philadelphia contributed to this report.

___

Online:

Raw video of crash: http://bit.ly/11Vf7JA

Source: http://news.yahoo.com/stuntwoman-pilot-killed-ohio-air-show-crash-073948128.html

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Microsoft reportedly pondered buying Nokia, bailed

Microsoft reportedly was in talks to buy Nokia's device unit, but talks broke down.

According to the Wall Street Journal, the move, which isn't all that surprising given the companies' tight partnership on Windows Phone, is the second report indicating that Nokia may be on the block. Huawei may also be interested in buying Nokia.

The plan was to combine Microsoft with a device maker with scale and then go after the likes of Apple and Samsung. In theory Nokia would give Microsoft the scale to crank out Windows-based tablets as well phones. What's unclear is whether actually owning Nokia would provide any real benefit to Microsoft's market share.

It's also notable that the Journal story noted that Microsoft walked away due to Nokia's placement in the smartphone pecking order. That reality could indicate that Microsoft thinks it needs a new horse to make a dent in the mobile market. Samsung is closely aligned with Google's Android.

Microsoft is in a battle with BlackBerry to be the No. 3 smartphone platform. Windows Phone is ahead for now, but BlackBerry's Q10 appears to be selling well. In either case, Microsoft and BlackBerry are vying to be a distant third to Apple and Samsung.

Source: http://feedproxy.google.com/~r/zdnet/thebigquestion/~3/bh0hbMThXiA/

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If you are a skilled gamer or beginner, the next report has something for you! Learn about the most recent winning methods, cheat requirements, savings and hottest features developing soon. No matter what your game or goal in playing, you are sure to locate something new and useful in the recommendations listed below.

And you stumble upon still another player who appears to be aggravating other people (or you, specifically) intentionally, don?t go on it personally, if you are playing a game title on line. This really is called ?Griefing,? and it is the gambling exact carbon copy of Internet trolling. Griefers are just out for negative focus, and they are given by you what they are looking for if you connect to them. Don?t get emotionally invested in what?s happening and simply make an effort to ignore it.

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Go through the back of the package, If you?re purchasing a game as a gift and read what it says. Specially, if the overall game is for a kid, look for something that you believe can show doubtful content. There also needs to be considered a few images that give you some idea of what you are getting as well.

Create reviews for game titles. This can help others learn whether they need a, from the perspective of a person who owns the game and has played it. Write an evaluation that you would desire to read. So that you might help others make good choices, be informative and descriptive.

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Simply take computer game breaks. Sitting in the same position for too long could be dangerous to your current health. Push your self every half an hour hitting that pause button and walk across the room for somewhat. This can help the human body along with clear the mind.

Understand that some games contain multi-player options, which could expose your kids to others on the web. In this case, you should really be monitoring who your young ones are talking to, as you do not want them to get too involved with strangers. This can help to place your child in the best place possible.

Double jumping is something that you can do in lots of method games to give you that extra boost when you?re running in order to avoid your opponent. This can be a good tactic to use, because it generally requires when you?re in motion the jump button to be pressed by you twice.

If you are looking forward to the newest gaming programs, be prepared to wait somewhat longer. Console gaming methods are normally a loss for the maker. The amount of research and development involved makes them maybe not successful when released. On the rear end on the on line purchases and games the money is made by the manufacturers.

Games may improve our lives in so many interesting ways. Game play can improve your athletic reactions, GPA if not your power to put together a fantastic party for your family! Hopefully this informative article has provided you with an engaging solution to learn more about video games and how to increase your advantages from them.

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Source: http://www.isk-network.de/on-line-video-gaming-resources-that-help-you-get-games-for-free/

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Mirren shares royal tea with cancer-stricken boy

Celebs

Randee Dawn TODAY contributor

11 hours ago

Nctlc Trust/Facebook

Helen Mirren with Oliver Burton.

Dame Helen Mirren all by herself is pretty terrific. But put the 70-year-old Oscar winner in the outfit of the Queen, and she wears it like a superhero.

Recently, she stormed outside mid-performance of her London show "The Audience" (in which she plays Queen Elizabeth II) to unload on noisy drummers (and later publicly wore a handmade T-shirt supporting their cause). But her latest deed goes one step further: Last week, she agreed to have tea with 10-year-old Oliver Burton, who has Down syndrome and has been battling cancer for much of his short life.

Burton was diagnosed with leukemia in 2006, and was recently given a terminal diagnosis, according to a Facebook page set up to support him. But he had one dying wish: To have afternoon tea with the Queen and visit Buckingham Palace, as reported by the Leicester Mercury.

A national trust designed to support cancer-stricken children requested the actual Queen Elizabeth II -- who couldn't work it into her schedule.

So Mirren stepped forward to invite him to the Gielgud Theatre to see her play the Queen -- and invited him backstage to share tea and cake and to meet the corgis who star in the play with her. There were even footmen.And naturally, she was in costume the entire time.

"Our incredibly brave Ollie has Tea with The Queen!" the National/Regional Children's Tumor Leukaemia and Cancer Trust posted on their page.

His mother Catherine told the Mercury, "Dame Helen was brilliant. She stayed in character the whole time and spent a lot of time talking to Oliver and drawing him out of himself. She signed his British flag, which he waves all the time."

She also knighted him, with her hand. Now, that's royal behavior.

Source: http://www.today.com/entertainment/helen-mirren-gives-royal-welcome-boy-down-syndrome-terminal-cancer-6C10018472

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Impoverished Malawi sells presidential jet for $15 mln

LILONGWE (Reuters) - Malawi's luxury presidential jet, bought by late leader Bingu wa Mutharika, has been sold for $15 million to raise cash for the impoverished African country, a government official said on Wednesday.

Mutharika, who left the economy on the brink of collapse after he picked a fight with donors whose support accounted for almost 40 percent of the budget, bought the jet for $22 million in 2009. He said the plane matched his status and was cheaper than flying commercially.

Britain, Malawi's main bilateral donor, criticised the purchase and reduced its aid budget to Mutharika's government by 3 million pounds because if it.

President Joyce Banda, who took office in April last year after Mutharika died of a heart attack, made the sale of the jet a priority as she sought to repair the economic damage.

Chintu Phiri, principal secretary in the office of the President and Cabinet, told Reuters that Virgin Islands company Bohnox Enterprise Ltd had beaten three other bidders for the 14-passenger Dassault Falcon 900EX aircraft. "We have accepted their offer and we are waiting to hear from them," Phiri said.

The plane reportedly cost Malawi about $300,000 a year in maintenance and insurance.

Since taking office, Banda has also cut her salary by 30 percent, pledged to sell off 35 Mercedes Benz cars used by her cabinet and introduced a host of austerity measures.

Her early popularity has faded, however, due to an IMF-backed devaluation of the kwacha currency that caused inflation to spike to more than 35 percent a year.

Source: http://news.yahoo.com/impoverished-malawi-sells-presidential-jet-15-mln-095422594.html

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